LRRTM3 anticorps (C-Term)

N° du produit ABIN1887246

Détail du produit anti-LRRTM3 anticorps

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Épitope: C-Term

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRTM3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the carboxy terminus of human LRRTM3.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur LRRTM3

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Autre désignation: LRRTM3 (LRRTM3 Produits)

Synonymes: anticorps 9630044H04Rik, anticorps leucine rich repeat transmembrane neuronal 3, anticorps LRRTM3, anticorps lrrtm3, anticorps Lrrtm3

Sujet: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation.Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques.Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

NCBI Accession: NP_821079

Pathways: Synaptic Membrane