CARD11 anticorps (C-Term)

N° du produit ABIN1887457

Détail du produit anti-CARD11 anticorps

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: Synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur CARD11

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Autre désignation: CARMA1 (CARD11 Produits)

Synonymes: anticorps BENTA, anticorps BIMP3, anticorps CARMA1, anticorps PPBL, anticorps 0610008L17Rik, anticorps 2410011D02Rik, anticorps CARD11, anticorps LOC100232755, anticorps caspase recruitment domain family member 11, anticorps caspase recruitment domain family, member 11, anticorps caspase recruitment domain-containing protein 11, anticorps CARD11, anticorps Card11, anticorps LOC100550812, anticorps card11

Sujet: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkappaK complex, thereby regulating activation of the NF-kappaB transcription factor.Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

UniProt: Q9BXL7

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, BCR Signaling