GPR124 anticorps (Center)

N° du produit ABIN1887527

Détail du produit anti-GPR124 anticorps

Antigène: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Épitope: Center

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR124 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide near the center of human TEM5.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur GPR124

Antigène: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Autre désignation: TEM5 (GPR124 Produits)

Synonymes: anticorps TEM5, anticorps 8430414O08Rik, anticorps 9530074E10Rik, anticorps Tem5, anticorps mKIAA1531, anticorps MGC69043, anticorps si:dkey-208c22.2, anticorps GPR124, anticorps adhesion G protein-coupled receptor A2, anticorps adhesion G protein-coupled receptor A2 L homeolog, anticorps G-protein coupled receptor 124, anticorps ADGRA2, anticorps Adgra2, anticorps adgra2.L, anticorps adgra2, anticorps LOC616111

Sujet: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors.TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.These include TEMs such as TEM1, TEM5, TEM7 and TEM8.TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells.TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once.TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Synonyms: Tumor endothelial marker 5, G protein-coupled receptor 124, GPR124

UniProt: Q96PE1