FAM120A anticorps (Center)

N° du produit ABIN1887747

Détail du produit anti-FAM120A anticorps

Antigène: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM120A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): This antibody will not cross-reacti with FAM120B / PGCC1.

Purification: Affinity chromatography purified via peptide column

Immunogène: FAM120A antibody was raised against an 18 amino acid peptide from near the center of human FAM120A.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur FAM120A

Antigène: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Autre désignation: FAM120A (FAM120A Produits)

Synonymes: anticorps MGC89333, anticorps fam120a, anticorps C9orf10, anticorps Ossa, anticorps DNAPTP1, anticorps DNAPTP5, anticorps OSSA, anticorps RGD1306643, anticorps family with sequence similarity 120A, anticorps family with sequence similarity 120, member A, anticorps fam120a, anticorps Fam120a, anticorps FAM120A

Sujet: FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31.FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain.As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling.It may participate in mRNA transport in the cytoplasm.FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase.FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress.Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
Synonyms: Constitutive coactivator of PPAR-gamma-like protein 1, DNAPTP1, DNAPTP5, Oxidative stress-associated Src activator, OSSA

NCBI Accession: NP_055427