FRMPD2 anticorps (N-Term)

N° du produit ABIN1887902

Détail du produit anti-FRMPD2 anticorps

Antigène: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRMPD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide from near the amino terminus of human FRMPD2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur FRMPD2

Antigène: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Autre désignation: FRMPD2 (FRMPD2 Produits)

Synonymes: anticorps Frmpd2, anticorps Gm1582, anticorps ENSMUSG00000071536, anticorps FRMPD2, anticorps PDZD5C, anticorps PDZK4, anticorps PDZK5C, anticorps FERM and PDZ domain containing 2, anticorps putative protein FRMPD2-like, anticorps FERM and PDZ domain-containing protein 2, anticorps Frmpd2, anticorps FRMPD2, anticorps LOC100051923, anticorps LOC100348282, anticorps LOC100548446

Sujet: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL.FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1.Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation.Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
Synonyms: FERM and PDZ domain-containing 2, PDZD5C, PDZK5C

NCBI Accession: NP_001018081

Pathways: Cell-Cell Junction Organization