PARL anticorps (N-Term)

N° du produit ABIN1887908

Détail du produit anti-PARL anticorps

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide from near the amino terminus of human PARL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur PARL

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Autre désignation: PARL (PARL Produits)

Synonymes: anticorps PSARL, anticorps PSARL1, anticorps PSENIP2, anticorps RHBDS1, anticorps D16Ertd607e, anticorps PRO2207, anticorps Psarl, anticorps parl, anticorps zgc:112986, anticorps presenilin associated rhomboid like, anticorps presenilin associated, rhomboid-like, anticorps presenilin associated, rhomboid-like a, anticorps PARL, anticorps Parl, anticorps parla

Sujet: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins.PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals.In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis.Variations in this gene have been associated with increased risk for type 2 diabetes.PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2.Multiple isoforms of PARL are known to exist.
Synonyms: Presenilin-associated rhomboid-like protein, PSARL, PSARL1, PSNENIP2

UniProt: Q9H300

Pathways: Autophagy