SOX2 anticorps (N-Term)

N° du produit ABIN1887944

Détail du produit anti-SOX2 anticorps

Antigène: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide near the amino terminus of human SOX.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SOX2

Antigène: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Autre désignation: SOX2 (SOX2 Produits)

Synonymes: anticorps ANOP3, anticorps MCOPS3, anticorps RGD1565646, anticorps Sox-2, anticorps lcc, anticorps ysb, anticorps cb236, anticorps wu:fb83g04, anticorps wu:fc14d07, anticorps zgc:65860, anticorps zgc:77389, anticorps SRY-box2, anticorps Xsox-2, anticorps anop3, anticorps mcops3, anticorps sox-2, anticorps SRY-box 2, anticorps SRY box 2, anticorps SRY (sex determining region Y)-box 2, anticorps SRY-box 2 S homeolog, anticorps SOX2, anticorps Sox2, anticorps sox2, anticorps sox2.S

Sujet: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach.Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases.Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts.Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction.
Synonyms: Sex-determining region Y-box 2, SRY-box 2, ANOP3, MCOPS3

NCBI Accession: NP_003097

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis