SIPA1L1 anticorps (N-Term)

N° du produit ABIN1887972

Détail du produit anti-SIPA1L1 anticorps

Antigène: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIPA1L1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide from near the amino terminus of human SIPA1L1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SIPA1L1

Antigène: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Autre désignation: SIPA1L1 (SIPA1L1 Produits)

Synonymes: anticorps 4931426N11Rik, anticorps AW213287, anticorps Spar, anticorps mKIAA0440, anticorps SPAL, anticorps Spa-1, anticorps Spa1, anticorps E6TP1, anticorps cb600, anticorps id:ibd5092, anticorps sb:cb600, anticorps si:ch211-106p8.1, anticorps wu:fc43g06, anticorps signal induced proliferation associated 1 like 1, anticorps signal-induced proliferation-associated 1 like 1, anticorps SIPA1L1, anticorps sipa1l1, anticorps Sipa1l1

Sujet: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs.SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses.Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1.CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
Synonyms: Signal-induced proliferation associated-like protein 1, E6TP1

NCBI Accession: NP_056371