DARC anticorps (N-Term)

N° du produit ABIN1888072

Détail du produit anti-DARC anticorps

Antigène: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DARC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide from near the amino terminus of human DARC.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur DARC

Antigène: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Autre désignation: DARC (DARC Produits)

Synonymes: anticorps DARC, anticorps FY, anticorps ACKR1, anticorps CCBP1, anticorps CD234, anticorps Dfy, anticorps GPD, anticorps GpFy, anticorps WBCQ1, anticorps AA162249, anticorps Ackr1, anticorps ESTM35, anticorps Duffy blood group, chemokine receptor, anticorps atypical chemokine receptor 1 (Duffy blood group), anticorps atypical chemokine receptor 1, anticorps DARC, anticorps ACKR1, anticorps Ackr1

Sujet: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling.DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines.Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein.It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases.At least three isoforms of DARC are known to exist.
Synonyms: Duffy antigen, Fy glycoprotein, GpFy, Cell adhesion molecule 3, CADM3

UniProt: Q16570