UNC93B1 anticorps (N-Term)

N° du produit ABIN1888104

Détail du produit anti-UNC93B1 anticorps

Antigène: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC93B1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide from near the amino terminus of human Unc93b.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur UNC93B1

Antigène: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Autre désignation: Unc93b (UNC93B1 Produits)

Synonymes: anticorps UNC93, anticorps IIAE1, anticorps UNC93B, anticorps Unc-93B1, anticorps Unc93b, anticorps unc-93 homolog B1, TLR signaling regulator, anticorps unc-93 homolog B1 (C. elegans), anticorps UNC93B1, anticorps Unc93b1

Sujet: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C.elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling.Unlike Unc93a, another homolog of the C.elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction.Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Synonyms: Unc93b1, homolog of C.elegans Unc93

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades