Endonuclease G anticorps (N-Term)

N° du produit ABIN1888159

Détail du produit anti-Endonuclease G anticorps

Antigène: Endonuclease G (ENDOG)

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Endonuclease G est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: EndoG antibody was raised with a Synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur Endonuclease G

Antigène: Endonuclease G (ENDOG)

Autre désignation: EndoG (ENDOG Produits)

Synonymes: anticorps CG8862, anticorps Dmel\\CG8862, anticorps Tb08.10J17.140, anticorps Tb08.10J17.90, anticorps TBC1D13, anticorps endog, anticorps ENDOG, anticorps wu:fb79c08, anticorps zgc:110020, anticorps Endonuclease G, anticorps endonuclease G, anticorps putative endonuclease G, anticorps endonuclease G, mitochondrial, anticorps endonuclease G L homeolog, anticorps EndoG, anticorps Tc00.1047053506867.10, anticorps Tb927.8.4040, anticorps Tb927.8.4090, anticorps LBRM_10_0750, anticorps LMJF_10_0610, anticorps NAEGRDRAFT_78507, anticorps ENDOG, anticorps endog, anticorps eNDOG, anticorps LOC100529218, anticorps Endog, anticorps endog.L

Sujet: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death.The activities of caspase and nuclease are involved in the DNA fragmentation.Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45.Caspase and CAD independent DNA fragmentation also exists.Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD.EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C.elegans.EndooG also cleaves DNA in vitro.

Poids moléculaire: 35 kDa

NCBI Accession: NP_004426

Pathways: Apoptose