RAPGEF3 anticorps (N-Term)

N° du produit ABIN1888161

Détail du produit anti-RAPGEF3 anticorps

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF3 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): At least two isoforms of EPAC1 are known to exist, this antibody will detect both isoforms. EPAC1 antibody is predicted to not cross-react with EPAC2.

Purification: Affinity chromatography purified via peptide column

Immunogène: EPAC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human EPAC1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur RAPGEF3

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Autre désignation: EPAC1 (RAPGEF3 Produits)

Synonymes: anticorps RAPGEF3, anticorps epac, anticorps si:dkey-27m20.2, anticorps CAMP-GEFI, anticorps EPAC, anticorps EPAC1, anticorps HSU79275, anticorps bcm910, anticorps 2310016P22Rik, anticorps 9330170P05Rik, anticorps Epac, anticorps Epac1, anticorps Rap guanine nucleotide exchange factor 3, anticorps Rap guanine nucleotide exchange factor 3 S homeolog, anticorps Rap guanine nucleotide exchange factor (GEF) 3, anticorps RAPGEF3, anticorps rapgef3.S, anticorps rapgef3, anticorps Rapgef3

Sujet: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord.EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family.This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation.Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Synonyms: Rap guanine nuclear exchange factor 3, RAPGEF3, cAMPGEF-I, bcm910

NCBI Accession: NP_659099

Pathways: cAMP Metabolic Process