Presenilin 2 anticorps (N-Term)

N° du produit ABIN1944732

Cet anticorps anti-Presenilin 2 est un anticorps Lapin Polyclonal détectant Presenilin 2 dans WB et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour Presenilin 2 anticorps (N-Term) (ABIN1944732)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB30801

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 32-65, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PSEN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-65 amino acids from the N-terminal region of human PSEN2(Presenilin-2 NTF subunit).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Presenilin 2 (ABIN1944732)

Levy-Lahad, Poorkaj, Wang, Fu, Oshima, Mulligan, Schellenberg: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." dans: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).

Li, Ma, Potter: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).

Levy-Lahad, Wasco, Poorkaj, Romano, Oshima, Pettingell, Yu, Jondro, Schmidt, Wang: "Candidate gene for the chromosome 1 familial Alzheimer's disease locus." dans: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 973-7, (1995) (PubMed).

Rogaev, Sherrington, Rogaeva, Levesque, Ikeda, Liang, Chi, Lin, Holman, Tsuda: "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene." dans: Nature, Vol. 376, Issue 6543, pp. 775-8, (1995) (PubMed).

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: PSEN2

Sujet: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Poids moléculaire: 50140

ID gène: 5664

UniProt: P49810

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway