Lamin A/C anticorps (AA 400-450)

N° du produit ABIN2017592

Détail du produit anti-Lamin A/C anticorps

Antigène: Lamin A/C (LMNA)

Épitope: AA 400-450

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificité: Rabbit Anti-Lamin A+C Polyclonal Antibody detects endogenous levels of human and mouse Lamin A and Lamin C. It is predicted to react with rat Lamin A and Lamin C according to sequence homology.Positive Control: Hela, A431, Lovo and NIH/3T3

Réactivité croisée (Details): Rabbit Anti-Lamin A+C Polyclonal Antibody detects endogenous levels of human and mouse Lamin A and Lamin C. It is predicted to react with rat Lamin A and Lamin C according to sequence homology.Positive Control: Hela, A431, Lovo and NIH/3T3

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide within AA 400-450 of human Lamin A .

Isotype: IgG1

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 0.5-1 µg/mLFlow cytometry: 1-3 µg for 1 x 106 cellsOther Applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: Rabbit Anti-Lamin A+C Polyclonal Antibody should be stored lyophilized until use. It remains stable in lyophilized form for at least two years if stored at -20°C or below. The reconstituted antibody can be stored for two to three weeks at 2-8°C or for up to 12 months at -20°C or below. Avoid repeated freeze and thaw cycles.

Date de péremption: 12 months

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A+C (LMNA Produits)

Synonymes: anticorps CDCD1, anticorps CDDC, anticorps CMD1A, anticorps CMT2B1, anticorps EMD2, anticorps FPL, anticorps FPLD, anticorps FPLD2, anticorps HGPS, anticorps IDC, anticorps LDP1, anticorps LFP, anticorps LGMD1B, anticorps LMN1, anticorps LMNC, anticorps LMNL1, anticorps PRO1, anticorps Dhe, anticorps 2459, anticorps 74/76, anticorps CG6944, anticorps D5, anticorps DM[[O]], anticorps Dm, anticorps Dm(0), anticorps Dm0, anticorps Dm1, anticorps Dm2, anticorps DmLamin, anticorps DmO, anticorps Dm[[0]], anticorps Dm[[1]], anticorps Dm[[2]], anticorps Dm[[mit]], anticorps Dm[[o]], anticorps Dmel\\CG6944, anticorps Dmo, anticorps LAM, anticorps Lam Dm[[0]], anticorps Lam(Dm0), anticorps LamDm[[0]], anticorps LamDm[[o]], anticorps Lam[[Dm0]], anticorps Lamin Dm[[0]], anticorps jf27, anticorps l(2)04643, anticorps l(2)25Ec, anticorps l(2)gdh-7, anticorps l(2)gdh7, anticorps l(2)jf27, anticorps lam, anticorps lamDm0, anticorps lamDm[[0]], anticorps lamin, anticorps lamin Dm0, anticorps lamin Dm[[0]], anticorps misg, anticorps nlam, anticorps cb948, anticorps fk66d12, anticorps wu:fk66d12, anticorps lmna-A, anticorps fpl, anticorps idc, anticorps lfp, anticorps cddc, anticorps emd2, anticorps fpld, anticorps hgps, anticorps ldp1, anticorps lmn1, anticorps lmnc, anticorps pro1, anticorps cdcd1, anticorps cmd1a, anticorps cmt2b1, anticorps lgmd1b, anticorps Lamin-A, anticorps lamin-L(III)-like, anticorps lamin A/C, anticorps lamin A, anticorps Lamin, anticorps lamin A/C L homeolog, anticorps lamin-L(III)-like, anticorps LMNA, anticorps Lmna, anticorps Lam, anticorps lmna, anticorps lmna.L, anticorps LMINA

Sujet: Lamins are structural protein components of the nuclear lamina which contains 3 members: Lamin A, B and C in mammalian cells. Lamin A and lamin C are generated by alternative splicing from the same gene and share complete identity for the first 566 amino acids. Lamin A interacts with transcription factor SREBP1 via its C-terminal domain. The lamin A/C deficiency is probably associated with both defective nuclear mechanics and impaired transcriptional activation. The lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. Rabbit Anti-Lamin A+C Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 400-450 of human Lamin A (Swiss Prot: P02545).

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus