CBLL1 anticorps

N° du produit ABIN2192196

Détail du produit anti-CBLL1 anticorps

Antigène: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For Western blotting, immunofluorescence and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-CBLL1 (ABIN2192196)

Fujita, Krause, Scheffner, Zechner, Leddy, Behrens, Sommer, Birchmeier: "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex." dans: Nature cell biology, Vol. 4, Issue 3, pp. 222-31, (2002) (PubMed).

Détails sur CBLL1

Antigène: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Autre désignation: Hakai (CBLL1 Produits)

Synonymes: anticorps HAKAI, anticorps RNF188, anticorps zgc:55308, anticorps CBLL1, anticorps AI467391, anticorps Hakai, anticorps c-Cbl-like, anticorps cbll1, anticorps hakai, anticorps rnf188, anticorps Cbl proto-oncogene like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase, anticorps Casitas B-lineage lymphoma-like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog, anticorps CBLL1, anticorps cbll1.S, anticorps Cbll1, anticorps cbll1, anticorps cbll1.L

Sujet: The polyclonal antibody reacts with human Hakai, a c-Cbl-like protein. Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.