anticorps TAD, anticorps cTADS, anticorps MGC82176, anticorps CRTAM, anticorps CD355, anticorps cytotoxic and regulatory T-cell molecule, anticorps cytotoxic and regulatory T-cell molecule L homeolog, anticorps cytotoxic and regulatory T cell molecule, anticorps CRTAM, anticorps crtam.L, anticorps Crtam
Sujet
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A, MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.