JMJD2D anticorps

N° du produit ABIN2430337

Détail du produit anti-JMJD2D anticorps

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD2D est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant protein of human KDM4D

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur JMJD2D

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Autre désignation: KDM4D (KDM4D Produits)

Synonymes: anticorps JMJD2D, anticorps 4932416A15, anticorps Jmjd2d, anticorps KDM4D, anticorps lysine demethylase 4D, anticorps lysine-specific demethylase 4D, anticorps lysine (K)-specific demethylase 4D, anticorps KDM4D, anticorps LOC524768, anticorps Kdm4d, anticorps LOC617971, anticorps LOC100067461, anticorps LOC698455, anticorps LOC100514356

Sujet: JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.

Poids moléculaire: Calculated MW: 59 kDa

Pathways: L'effet Warburg