MCM4 anticorps

N° du produit ABIN2431647

Détail du produit anti-MCM4 anticorps

Antigène: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity purification

Immunogène: Synthetic peptide of human MCM4

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MCM4

Antigène: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Autre désignation: MCM4 (MCM4 Produits)

Synonymes: anticorps cdc21, anticorps CDC21, anticorps CDC54, anticorps NKCD, anticorps NKGCD, anticorps P1-CDC21, anticorps hCdc21, anticorps 19G, anticorps AI325074, anticorps AU045576, anticorps Cdc21, anticorps Mcmd4, anticorps mKIAA4003, anticorps mcdc21, anticorps cb1025, anticorps fc12c09, anticorps fj85g09, anticorps hm:zeh1616, anticorps wu:fc12c09, anticorps wu:fj85g09, anticorps zeh1616, anticorps minichromosome maintenance complex component 4 L homeolog, anticorps minichromosome maintenance complex component 4 S homeolog, anticorps minichromosome maintenance complex component 4, anticorps mcm4.L, anticorps mcm4.S, anticorps MCM4, anticorps mcm4, anticorps Mcm4

Sujet: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Poids moléculaire: Calculated MW: 97 kDa

NCBI Accession: NP_877423

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA