HSBP1 anticorps

N° du produit ABIN2458158

Détail du produit anti-HSBP1 anticorps

Antigène: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSBP1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HSBP1.

Information d'application

Indications d'application: HSBP1 antibody can be used for detection of HSBP1 by ELISA at 1:312500. HSBP1 antibody can be used for detection of HSBP1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store HSBP1 antibody at -20 °C.

Détails sur HSBP1

Antigène: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Autre désignation: HSBP1 (HSBP1 Produits)

Synonymes: anticorps HSBP1, anticorps npc-a-13, anticorps NPC-A-13, anticorps hsbp1, anticorps hsbp1a, anticorps 0610007A03Rik, anticorps AA408769, anticorps Hsp25, anticorps zgc:73224, anticorps heat shock factor binding protein 1 like 1, anticorps heat shock factor binding protein 1, anticorps Heat shock factor binding protein 1, anticorps heat shock factor binding protein 1 S homeolog, anticorps heat shock factor binding protein 1 L homeolog, anticorps heat shock factor binding protein 1b, anticorps HSBP1L1, anticorps HSBP1, anticorps Bm1_07370, anticorps hsbp1.S, anticorps hsbp1, anticorps hsbp1.L, anticorps Hsbp1, anticorps hsbp1b

Sujet: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1 (HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1 (HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

Poids moléculaire: 8 kDa

ID gène: 3281

NCBI Accession: NP_001528

UniProt: O75506

Pathways: SARS-CoV-2 Protein Interactome