LIN7C anticorps

N° du produit ABIN2458686

Détail du produit anti-LIN7C anticorps

Antigène: LIN7C (Lin-7 Homolog C (LIN7C))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIN7C est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LIN7C.

Information d'application

Indications d'application: LIN7C antibody can be used for detection of LIN7C by ELISA at 1:312500. LIN7C antibody can be used for detection of LIN7C by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store LIN7C antibody at -20 °C.

Détails sur LIN7C

Antigène: LIN7C (Lin-7 Homolog C (LIN7C))

Autre désignation: LIN7C (LIN7C Produits)

Synonymes: anticorps LIN7C, anticorps fb75b09, anticorps wu:fb75b09, anticorps zgc:101881, anticorps LIN-7-C, anticorps LIN-7C, anticorps MALS-3, anticorps MALS3, anticorps VELI3, anticorps 9130007B12Rik, anticorps AI303698, anticorps AU019331, anticorps AW125731, anticorps D2Ertd520e, anticorps Veli3, anticorps lin-7 homolog C, crumbs cell polarity complex component, anticorps lin-7 homolog C L homeolog, anticorps lin-7 homolog C (C. elegans), anticorps LIN7C, anticorps lin7c.L, anticorps lin7c, anticorps Lin7c

Sujet: LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Poids moléculaire: 22 kDa

ID gène: 55327

NCBI Accession: NP_060832

UniProt: Q9NUP9

Pathways: Synaptic Membrane