PPARD anticorps

N° du produit ABIN2460599

Détail du produit anti-PPARD anticorps

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPARD est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPARD.

Information d'application

Indications d'application: PPARD antibody can be used for detection of PPARD by ELISA at 1:1562500. PPARD antibody can be used for detection of PPARD by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PPARD antibody at -20 °C.

Détails sur PPARD

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Autre désignation: PPARD (PPARD Produits)

Synonymes: anticorps FAAR, anticorps NR1C2, anticorps NUC1, anticorps NUCI, anticorps NUCII, anticorps PPARB, anticorps NUC-1, anticorps Nr1c2, anticorps PPAR-beta, anticorps PPAR-delta, anticorps PPAR[b], anticorps PPARdelta, anticorps Pparb, anticorps Pparb/d, anticorps PPARBETA, anticorps ppard, anticorps pparb, anticorps PPARD, anticorps PPAR-D/B, anticorps peroxisome proliferator activated receptor delta, anticorps peroxisome proliferator activator receptor delta, anticorps peroxisome proliferator activated receptor delta S homeolog, anticorps peroxisome proliferator-activated receptor delta, anticorps PPARD, anticorps Ppard, anticorps ppard.S, anticorps ppard

Sujet: PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Poids moléculaire: 49 kDa

ID gène: 5467

NCBI Accession: NP_006229

UniProt: Q03181

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation