NXF1 anticorps

N° du produit ABIN2462207

Détail du produit anti-NXF1 anticorps

Antigène: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NXF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NXF1.

Information d'application

Indications d'application: NXF1 antibody can be used for detection of NXF1 by ELISA at 1:312500. NXF1 antibody can be used for detection of NXF1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NXF1 antibody at -20 °C.

Détails sur NXF1

Antigène: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Autre désignation: NXF1 (NXF1 Produits)

Synonymes: anticorps im:7156527, anticorps wu:fc12d06, anticorps MGC82224, anticorps NXF1, anticorps tap, anticorps mex67, anticorps MEX67, anticorps TAP, anticorps Mex67, anticorps Mvb1, anticorps Tap, anticorps Mex67h, anticorps nuclear RNA export factor 1, anticorps nuclear RNA export factor 1 S homeolog, anticorps Nuclear RNA export factor 1, anticorps nxf1, anticorps nxf1.S, anticorps NXF1, anticorps LOC100113601, anticorps Tsp_03999, anticorps Nxf1, anticorps nxf-1

Sujet: NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly (A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly (A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.

Poids moléculaire: 68 kDa, 40 kDa

ID gène: 10482

NCBI Accession: NP_006353

UniProt: Q9UBU9