EBP anticorps

N° du produit ABIN2463004

Détail du produit anti-EBP anticorps

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EBP est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EBP.

Information d'application

Indications d'application: EBP antibody can be used for detection of EBP by ELISA at 1:12500. EBP antibody can be used for detection of EBP by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store EBP antibody at -20 °C.

Détails sur EBP

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Autre désignation: EBP (EBP Produits)

Synonymes: anticorps cdpx2, anticorps cho2, anticorps cpx, anticorps cpxd, anticorps zgc:91895, anticorps CDPX2, anticorps CHO2, anticorps CPX, anticorps CPXD, anticorps AI255399, anticorps Pabp, anticorps Td, anticorps mSI, anticorps emopamil binding protein (sterol isomerase), anticorps emopamil binding protein (sterol isomerase) L homeolog, anticorps phenylalkylamine Ca2+ antagonist (emopamil) binding protein, anticorps Ebp, anticorps ebp.L, anticorps ebp, anticorps EBP

Sujet: EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. EBP shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of EBP is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).

Poids moléculaire: 26 kDa

ID gène: 10682

NCBI Accession: NP_006570

UniProt: Q15125