HSD11B2 anticorps (AA 181-405)

N° du produit ABIN2468177

Détail du produit anti-HSD11B2 anticorps

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Épitope: AA 181-405

Reactivité: Humain, Rat, Poulet

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B2 est non-conjugé

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Information d'application

Indications d'application: Corticosteroid 11-beta-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-beta-dehydrogenase, isozyme 2 by Western Blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Agent conservateur: Without preservative

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C/-20 °C

Stockage commentaire: HSD11B2 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Détails sur HSD11B2

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Autre désignation: HSD11B2 (HSD11B2 Produits)

Synonymes: anticorps MGC81883, anticorps 11-HSD2, anticorps AME, anticorps AME1, anticorps HSD11K, anticorps HSD2, anticorps SDR9C3, anticorps 11HSD2, anticorps HSD11B2, anticorps hydroxysteroid (11-beta) dehydrogenase 2 L homeolog, anticorps hydroxysteroid 11-beta dehydrogenase 2, anticorps hsd11b2.L, anticorps HSD11B2, anticorps Hsd11b2

Sujet: FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.

Poids moléculaire: 44.1 kDa (calculated)

ID gène: 3291

NCBI Accession: NP_000187

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones