ATM anticorps (AA 980-1152)

N° du produit ABIN2469773

L’anticorps Souris Monoclonal anti-ATM a été validé pour WB, IHC et IP. Il convient pour détecter ATM dans des échantillons de Humain.

Aperçu rapide pour ATM anticorps (AA 980-1152) (ABIN2469773)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 3-00E-008

Détail du produit anti-ATM anticorps

Épitope: AA 980-1152

Purification: Protein G Column

Immunogène: ATM monoclonal antibody was raised against recombinant protein expressed in E. coli, amino acids 980 - 1512 of ATM (Human).

Isotype: IgG1

Information d'application

Indications d'application: ATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4. No preservatives added.

Agent conservateur: Without preservative

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store ATM antibody at -20 °C.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: ATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.

ID gène: 472

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus