BCL10 anticorps (AA 5-19)

N° du produit ABIN264992

L’anticorps anti-BCL10 Polyclonal Lapin est utilisé pour la détection de BCL10 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour BCL10 anticorps (AA 5-19) (ABIN264992)

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL10 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BCL10 anticorps

Épitope: AA 5-19

Specificité: This antibody reacts to BCL10.

Purification: Purified

Immunogène: Synthetic peptide corresponding to amino acids 5 to 19 of the human BCL-10 protein.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 μg/mL. Detects a 31 kDa band in Raji whole cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline solution containing 0.02 % sodium azide as a preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.

Détails sur BCL10

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Autre désignation: Bcl-10

Sujet: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6). Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation (1,2,4,6). Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation (3.6). BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy (1,5). BCL10 is expressed in many human and murine tissues and cell lines (2-6).Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10

ID gène: 8915

NCBI Accession: NP_003912

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins