Stargazin anticorps

N° du produit ABIN265040

Détail du produit anti-Stargazin anticorps

Antigène: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stargazin est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to CACNG2.

Purification: Purified

Immunogène: Synthetic peptide derived from the rat calcium channel gamma2 subunit conjugated to KLH

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur Stargazin

Antigène: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Autre désignation: CACNG2 (CACNG2 Produits)

Synonymes: anticorps cacng2, anticorps zgc:64200, anticorps CACNG2, anticorps stargazin, anticorps AW060990, anticorps B230105C07Rik, anticorps B930041E13Rik, anticorps stargazer, anticorps stg, anticorps wag, anticorps waggler, anticorps Ipr328, anticorps MRD10, anticorps calcium voltage-gated channel auxiliary subunit gamma 2, anticorps calcium channel, voltage-dependent, gamma subunit 2a, anticorps calcium channel, voltage-dependent, gamma subunit 2, anticorps CACNG2, anticorps cacng2a, anticorps cacng2, anticorps Cacng2

Sujet: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel2. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 2 subunits, or stargazin, the product of a gene mutated in the stargazer mouse, is a homolog of the gamma 1 channel and is selectively expressed in the brain. It is considered to be a putative neuronal Ca2+ channel subtype mainly based on its homology to the gamma 1.Synonyms: Neuronal voltage-gated calcium channel gamma-2 subunit, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, Voltage-dependent calcium channel gamma-2 subunit

ID gène: 10369

NCBI Accession: NP_006069

UniProt: Q9Y698

Pathways: Skeletal Muscle Fiber Development