COPS3 anticorps

N° du produit ABIN265485

Détail du produit anti-COPS3 anticorps

Antigène: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of JAB1/COPS3 protein. (region surrounding Met408)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur COPS3

Antigène: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Autre désignation: COPS3 (COPS3 Produits)

Synonymes: anticorps CG18332, anticorps CH3, anticorps Csn3, anticorps DCH3, anticorps Dch3, anticorps Dmel\\CG18332, anticorps FBgn0027055, anticorps dCSN3, anticorps COPS3, anticorps CSN3, anticorps DKFZp468P1922, anticorps Sgn3, anticorps wu:fc32a02, anticorps wu:fk59f01, anticorps zgc:111903, anticorps zgc:55643, anticorps zgc:77615, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 13, anticorps COP9 SIGNALOSOME SUBUNIT 3, anticorps F18O22.40, anticorps F18O22_40, anticorps FUS11, anticorps FUSCA 11, anticorps SGN3, anticorps csn3, anticorps COP9 signalosome subunit 3, anticorps Proteasome component (PCI) domain protein, anticorps COP9 signalosome subunit 3 L homeolog, anticorps COP9 signalosome complex subunit 3, anticorps CSN3, anticorps cops3, anticorps COPS3, anticorps Cops3, anticorps COP13, anticorps cops3.L, anticorps csn-3

Sujet: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation domain-binding protein), interacts with c-Jun and Jun D, but not with Jun B or v-Jun. This interaction enhances the transactivating ability of Jun proteins by stabilizing their binding to the TRE.Synonyms: COP9 signalosome complex subunit 3, CSN3, JAB1-containing signalosome subunit 3, SGN3, Signalosome subunit 3

Poids moléculaire: approx. 47 kDa

ID gène: 8533

NCBI Accession: NP_001186054

UniProt: Q9UNS2

Pathways: Cycle Cellulaire