The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
anticorps 1810061I13Rik, anticorps CLEC2, anticorps CLEC2B, anticorps PRO1384, anticorps QDED721, anticorps Clec-2, anticorps Clec2, anticorps CLEC1B, anticorps RGD1563517, anticorps CLEC9A, anticorps C-type lectin domain family 1 member B, anticorps C-type lectin domain family 1, member b, anticorps C-type lectin domain family 1, member B, anticorps CLEC1B, anticorps Clec1b
Classe de substances
Viral Protein
Sujet
CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.