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TNFRSF18 anticorps
TNFRSF18
Reactivité: Humain
IF, ICFC
Hôte: Souris
Monoclonal
621
unconjugated
N° du produit ABIN2664611
Détail du produit anti-TNFRSF18 anticorps
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Antigène
Voir toutes TNFRSF18 Anticorps
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Reactivité
Toutes les réactivités sur TNFRSF18 Anticorps
Humain
Hôte
Toutes les hôtes sur TNFRSF18 Anticorps
Souris
Clonalité
Toutes les clonalités sur TNFRSF18 Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers TNFRSF18 Anticorps
Cet anticorp TNFRSF18 est non-conjugé
Application
Tous les applications à travers TNFRSF18 Anticorps.
Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
Purification
The antibody was purified by affinity chromatography.
Clone
621
Isotype
IgG1 kappa
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Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
The antibody solution should be stored undiluted between 2°C and 8°C.
Détails sur TNFRSF18
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Antigène
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Autre désignation
CD357 (TNFRSF18 Produits )
Synonymes
anticorps GITR, anticorps TNFRSF18, anticorps AITR, anticorps Gitr, anticorps CD357, anticorps GITR-D, anticorps TNF receptor superfamily member 18, anticorps tumor necrosis factor receptor superfamily, member 18, anticorps TNFRSF18, anticorps Tnfrsf18
Sujet
GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
Pathways
Cancer Immune Checkpoints
Vus récemment
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