C-Type Lectin Domain Family 1, Member B (CLEC1B) anticorps

N° du produit ABIN2664892

Détail du produit

Antigène: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: The antibody was purified by affinity chromatography.

Clone: 17D9-CLEC2

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détail du antigène

Antigène: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Autre désignation: CLEC2 (CLEC1B Produits)

Synonymes: anticorps 1810061I13Rik, anticorps CLEC2, anticorps CLEC2B, anticorps PRO1384, anticorps QDED721, anticorps Clec-2, anticorps Clec2, anticorps CLEC1B, anticorps RGD1563517, anticorps CLEC9A, anticorps C-type lectin domain family 1 member B, anticorps C-type lectin domain family 1, member b, anticorps C-type lectin domain family 1, member B, anticorps CLEC1B, anticorps Clec1b

Classe de substances: Viral Protein

Sujet: CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.