KLRK1 anticorps
-
- Antigène Voir toutes KLRK1 Anticorps
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp KLRK1 est non-conjugé
-
Application
- Flow Cytometry (FACS)
- Marque
- Ultra-LEAF™
- Purification
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
-
Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.
- Clone
- 1D11
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product KLRK1 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Agent conservateur
- Azide free
- Conseil sur la manipulation
- This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
- Antigène
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- Autre désignation
- CD314 (KLRK1 Produits)
- Synonymes
- anticorps KLRK1, anticorps NKG2D, anticorps CD314, anticorps D12S2489E, anticorps KLR, anticorps NKG2-D, anticorps D6H12S2489E, anticorps Nkg2d, anticorps Nkrp2, anticorps killer cell lectin like receptor K1, anticorps killer cell lectin-like receptor subfamily K, member 1, anticorps NKG2D protein, anticorps KLRK1, anticorps Klrk1, anticorps NKG2D
- Sujet
- CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NK cells, CD8+ T cells, γ/ δ T cells, and in vitro induced LAK cells. Several molecules have been identified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, but attains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being a primary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligands plays a role in the immune surveillance against pathogen and tumor cells, and in the pathogenesis of autoimmune diseases.
- Pathways
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
-