BAFF anticorps

N° du produit ABIN2688855

Détail du produit anti-BAFF anticorps

Antigène: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BAFF est non-conjugé

Application: ELISA

Marque: BD Pharmingen™

Attributs du produit: Antibody H32-406 reacts with B-lymphocyte stimulator protein (Blys), also known as BAFF (B cell activating factor) and is a member of the TNF ligand superfamily. Members of the TNF receptor and ligand superfamily play a critical role in regulating immune responses. Blys is a type II membrane protein expressed on cells of myeloid lineage including monocytes, dendritic cells, and activated T cells. Blys exists in both a membrane-bound and soluble form. In its soluble form, Blys is a potent B cell growth factor in costimulation assays, suggesting its biological role in monocyte-driven B cell activation. Blys has also been linked to B cell hyperplasia and autoimmunity. Human Blys sandwich ELISA curve: The curve was generated by a sandwich ELISA using the purified H32-406 as capture antibody, doubling dilutions of recombinant human Blys protein and biotin H32-544 (Cat. No. 558290) as detection antibody. Streptavidin-HRP (Cat. No. 554066) plus TMB substrate (Cat. No. 555214)were used to develop the ELISA.

BD Pharmingen™ Purified Mouse anti-Human Blys (BAFF) - Purified - Clone H32-406 - Isotype Mouse IgG1, κ - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: H32

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-BAFF (ABIN2688855)

Craxton, Magaletti, Ryan, Clark: "Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF." dans: Blood, Vol. 101, Issue 11, pp. 4464-71, (2003) (PubMed).

Mackay, Schneider, Rennert, Browning: "BAFF AND APRIL: a tutorial on B cell survival." dans: Annual review of immunology, Vol. 21, pp. 231-64, (2003) (PubMed).

Khare, Sarosi, Xia, McCabe, Miner, Solovyev, Hawkins, Kelley, Chang, Van, Ross, Delaney, Wang, Lacey, Boyle, Hsu: "Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3370-5, (2000) (PubMed).

Moore, Belvedere, Orr, Pieri, LaFleur, Feng, Soppet, Charters, Gentz, Parmelee, Li, Galperina, Giri, Roschke, Nardelli, Carrell, Sosnovtseva, Greenfield, Ruben, Olsen, Fikes, Hilbert: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." dans: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, (1999) (PubMed).

Détails sur BAFF

Antigène: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Autre désignation: Blys BAFF (TNFSF13B Produits)

Synonymes: anticorps BAFF, anticorps BLYS, anticorps CD257, anticorps DTL, anticorps TALL-1, anticorps TALL1, anticorps THANK, anticorps TNFSF20, anticorps ZTNF4, anticorps BAFF-R, anticorps BAFFR, anticorps BROMIX, anticorps CD268, anticorps CVID4, anticorps prolixin, anticorps TNFSF13B, anticorps RGD1561519, anticorps RGD1560810, anticorps BLyS, anticorps D8Ertd387e, anticorps zTNF4, anticorps 2010006P15Rik, anticorps Baffr, anticorps Bcmd, anticorps Bcmd-1, anticorps Bcmd1, anticorps Lvis22, anticorps zgc:172115, anticorps TNF superfamily member 13b, anticorps TNF receptor superfamily member 13C, anticorps tumor necrosis factor (ligand) superfamily, member 13b, anticorps tumor necrosis factor receptor superfamily, member 13c, anticorps tumor necrosis factor superfamily member 13b, anticorps TNFSF13B, anticorps TNFRSF13C, anticorps Tnfsf13b, anticorps Tnfrsf13c, anticorps tnfsf13b

Pathways: Signalisation NF-kappaB, Production of Molecular Mediator of Immune Response