FLT3 anticorps

N° du produit ABIN2688960

Détail du produit anti-FLT3 anticorps

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: Reacts with FMS-like tyrosine kinase 3 (flt3), a 155-160 kD, class III tyrosine kinase receptor (CD135), which is structurally related to the receptors for PDGF, SCF-1 and kit ligand. CD135 is expressed on multipotential, myelomonocytic and primitive B-cell progenitors. The most primitive hematopoietic progenitor cells express low levels of CD135. CD135 plays the role of growth factor receptor for early hematopoietic progenitors. Reports from studies with knockout mice have shown that targeted CD135 disruption impaired the development of primitive progenitor cells of all hematopoietic lineages with significant impact on lymphopoietic precursors. Profile of REH cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD135 - Purified - Clone 4G8 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 4G8

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-FLT3 (ABIN2688960)

Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: "Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase." dans: Blood, Vol. 90, Issue 1, pp. 111-25, (1997) (PubMed).

Rusten, Lyman, Veiby, Jacobsen: "The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro." dans: Blood, Vol. 87, Issue 4, pp. 1317-25, (1996) (PubMed).

Mackarehtschian, Hardin, Moore, Boast, Goff, Lemischka: "Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors." dans: Immunity, Vol. 3, Issue 1, pp. 147-61, (1995) (PubMed).

Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: "Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells." dans: Blood, Vol. 82, Issue 4, pp. 1110-9, (1993) (PubMed).

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: CD135 (FLT3 Produits)

Synonymes: anticorps FLT3, anticorps B230315G04, anticorps CD135, anticorps Flk-2, anticorps Flk2, anticorps Flt-3, anticorps Ly72, anticorps wmfl, anticorps FLK-2, anticorps FLK2, anticorps STK1, anticorps fms related tyrosine kinase 3, anticorps FMS-like tyrosine kinase 3, anticorps fms-related tyrosine kinase 3, anticorps FLT3, anticorps Flt3

Pathways: Signalisation RTK