CD137 anticorps

N° du produit ABIN2688961

Détail du produit anti-CD137 anticorps

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD137 est non-conjugé

Application: ELISA

Marque: BD Pharmingen™

Attributs du produit: Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naive T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.

BD Pharmingen™ Purified Anti-Human CD137 - Purified - Clone h41BB-M127 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: H41BB

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD137 (ABIN2688961)

Kim, Broxmeyer: "Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells." dans: Journal of hematotherapy & stem cell research, Vol. 10, Issue 4, pp. 441-9, (2001) (PubMed).

Michel, Schwarz: "Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes." dans: Cytokine, Vol. 12, Issue 6, pp. 742-6, (2000) (PubMed).

Vinay, Kwon: "Role of 4-1BB in immune responses." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 481-9, (1999) (PubMed).

Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." dans: Nature medicine, Vol. 3, Issue 6, pp. 682-5, (1997) (PubMed).

Détails sur CD137

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Autre désignation: CD137 (TNFRSF9 Produits)

Synonymes: anticorps TNFRSF9, anticorps zgc:136557, anticorps 4-1BB, anticorps CD137, anticorps CDw137, anticorps ILA, anticorps A930040I11Rik, anticorps AA408498, anticorps AI325004, anticorps Cd137, anticorps Ly63, anticorps tumor necrosis factor receptor superfamily member 9, anticorps TNF receptor superfamily member 9, anticorps tumor necrosis factor receptor superfamily, member 9a, anticorps tumor necrosis factor receptor superfamily, member 9, anticorps TNFRSF9, anticorps tnfrsf9a, anticorps Tnfrsf9

Sujet: Synonyms: 4-1BB, CDw137

Pathways: Cancer Immune Checkpoints