KIR2DL3 anticorps

N° du produit ABIN2688999

Détail du produit anti-KIR2DL3 anticorps

Antigène: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIR2DL3 est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: Reacts with a 50 - 58 kDa type I glycoprotein molecule of the killer cell inhibitory receptor (KIR) family of proteins. CD158b has also been known as GLI83, p50.2, or p58.2. CD158b is composed of two extracellular Ig-like domains. It is expressed on a subset of NK cells and it may also be present on rare T cells (either CD3/TCR αβ+, or CD3/TCR γδ+). CD158b regulates NK cell mediated cytolytic activity by interacting with HLA-C alleles (Cw 1, 3, 7 and 8). This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD158b - Purified - Clone CH-L - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: CH

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-KIR2DL3 (ABIN2688999)

Kim, Chwae, Kim, Choi, Park, Kim: "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3875-82, (1997) (PubMed).

Cambiaggi, Orengo, Meazza, Sforzini, Tazzari, Lauria, Raspadori, Zambello, Semenzato, Moretta, Ferrini: "The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function." dans: Blood, Vol. 87, Issue 6, pp. 2369-75, (1996) (PubMed).

Colonna, Samaridis: "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." dans: Science (New York, N.Y.), Vol. 268, Issue 5209, pp. 405-8, (1995) (PubMed).

Ferrini, Cambiaggi, Meazza, Sforzini, Marciano, Mingari, Moretta: "T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function." dans: European journal of immunology, Vol. 24, Issue 10, pp. 2294-8, (1994) (PubMed).

Détails sur KIR2DL3

Antigène: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Autre désignation: CD158b (KIR2DL3 Produits)

Synonymes: anticorps CD158B2, anticorps CD158b, anticorps GL183, anticorps KIR-023GB, anticorps KIR-K7b, anticorps KIR-K7c, anticorps KIRCL23, anticorps NKAT, anticorps NKAT2, anticorps NKAT2A, anticorps NKAT2B, anticorps p58, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3, anticorps KIR2DL3

Pathways: Cancer Immune Checkpoints