The DX11 monoclonal antibody specifically binds to CD226 which is also known as DNAX accessory molecule-1 (DNAM-1), Platelet and T cell activation antigen 1 (PTA1), or T lineage-specific activation antigen 1 antigen (TLiSA1). CD226 is a 65 kDa type 1 transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. CD226 is expressed on the majority of T cells, NK cells, monocytes, platelets, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. CD226 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. CD226 is a tyrosine phosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)- or NK cell-mediated cytotoxicity. The DX11 antibody inhibits T- and NK cell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells. Profile of peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Store undiluted at 4°C.
Shibuya, Campbell, Hannum, Yssel, Franz-Bacon, McClanahan, Kitamura, Nicholl, Sutherland, Lanier, Phillips: "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." dans: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).