CD31 anticorps (Biotin)

N° du produit ABIN2689177

Détail du produit anti-CD31 anticorps (Biotin)

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD31 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: The 390 monoclonal antibody specifically binds to CD31, also known as PECAM-1 (platelet endothelial cell adhesion molecule). CD31 is a ~130 kDa integral membrane glycoprotein, a member of the immunoglobulin superfamily, that mediates homophilic and heterophilic cell-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is weakly expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development, this alternative splicing is involved in regulation of ligand specificity. CD38 and vitronectin receptor (αvβ3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The 390 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31.

BD Pharmingen™ Biotin Rat Anti-Mouse CD31 - Biotin - Clone 390 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: C3H/HeJ mouse hematopoietic progenitor cell line 32D

Clone: 390

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing protein stabilizer and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD31 (Biotin) (ABIN2689177)

Duncan, Andrew, Takimoto, Kaufman, Yoshida, Spellberg, de la Pompa, Elia, Wakeham, Karan-Tamir, Muller, Senaldi, Zukowski, Mak: "Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 3022-30, (1999) (PubMed).

Horenstein, Stockinger, Imhof, Malavasi: "CD38 binding to human myeloid cells is mediated by mouse and human CD31." dans: The Biochemical journal, Vol. 330 ( Pt 3), pp. 1129-35, (1998) (PubMed).

Buck, Edelman, Buck, Kennedy, Baldwin: "Expression patterns of adhesion receptors in the developing mouse lung: functional implications." dans: Cell adhesion and communication, Vol. 4, Issue 2, pp. 69-87, (1997) (PubMed).

DeLisser, Christofidou-Solomidou, Strieter, Burdick, Robinson, Wexler, Kerr, Garlanda, Merwin, Madri, Albelda: "Involvement of endothelial PECAM-1/CD31 in angiogenesis." dans: The American journal of pathology, Vol. 151, Issue 3, pp. 671-7, (1997) (PubMed).

Famiglietti, Sun, DeLisser, Albelda: "Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity." dans: The Journal of cell biology, Vol. 138, Issue 6, pp. 1425-35, (1997) (PubMed).

Iguchi, Okuyama, Koguma, Obinata, Yanai: "Selective stimulation of granulopoiesis in vitro by established bone marrow stromal cells." dans: Cell structure and function, Vol. 22, Issue 3, pp. 357-64, (1997) (PubMed).

Ling, Luxenberg, Wang, Nickbarg, Leenen, Neben, Kobayashi: "Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31)." dans: European journal of immunology, Vol. 27, Issue 2, pp. 509-14, (1997) (PubMed).

Rosenblum, Nelson, Wormley, Werner, Wang, Shih: "Role of platelet-endothelial cell adhesion molecule (PECAM) in platelet adhesion/aggregation over injured but not denuded endothelium in vivo and ex vivo." dans: Stroke; a journal of cerebral circulation, Vol. 27, Issue 4, pp. 709-11, (1996) (PubMed).

Piali, Hammel, Uherek, Bachmann, Gisler, Dunon, Imhof: "CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium." dans: The Journal of cell biology, Vol. 130, Issue 2, pp. 451-60, (1995) (PubMed).

Buck, Baldwin, DeLisser, Mickanin, Shen, Kennedy, Chen, Edelman, Albelda: "Cell adhesion receptors and early mammalian heart development: an overview." dans: Comptes rendus de l'Acade?mie des sciences. Se?rie III, Sciences de la vie, Vol. 316, Issue 9, pp. 838-59, (1994) (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." dans: Immunology today, Vol. 15, Issue 10, pp. 490-5, (1994) (PubMed).

Détails sur CD31

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Autre désignation: CD31 (PECAM1 Produits)

Synonymes: anticorps CD31, anticorps CD31/EndoCAM, anticorps GPIIA', anticorps PECA1, anticorps PECAM-1, anticorps endoCAM, anticorps C85791, anticorps Cd31, anticorps Pecam, anticorps platelet/endothelial cell adhesion molecule 1, anticorps platelet and endothelial cell adhesion molecule 1, anticorps pecam1, anticorps PECAM1, anticorps Pecam1

Sujet: Synonyms: Platelet endothelial cell adhesion molecule, Pecam1, PECAM-1, Pecam-1

Pathways: Regulation of Actin Filament Polymerization