Cyclin L1 anticorps

N° du produit ABIN271776

Détail du produit anti-Cyclin L1 anticorps

Antigène: Cyclin L1 (CCNL1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin L1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Cyclin-L1 protein. (region surrounding Glu491)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Cyclin L1

Antigène: Cyclin L1 (CCNL1)

Autre désignation: Cyclin L1 (CCNL1 Produits)

Synonymes: anticorps ANIA6A, anticorps PRO1073, anticorps ania-6a, anticorps 2610030E23Rik, anticorps AU018493, anticorps Ccnl, anticorps Ania-6a, anticorps ccnl1, anticorps fd99b09, anticorps wu:fd99b09, anticorps zgc:55544, anticorps MCM2, anticorps cyclin-L1, anticorps MGC132032, anticorps bm-001, anticorps pro1073, anticorps MGC108436, anticorps Ccnl1, anticorps cyclin L1, anticorps cyclin L1b, anticorps cyclin-L1, anticorps cyclin L1 L homeolog, anticorps cyclin L1 S homeolog, anticorps CCNL1, anticorps Ccnl1, anticorps ccnl1b, anticorps LOC485730, anticorps ccnl1.L, anticorps ccnl1, anticorps LOC100136245, anticorps ccnl1.S

Sujet: Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle and, thereby, regulates the kinase activity. Cyclin L1 is a ubiquitously expressed nuclear protein that can be detected in higher levels in thymus. In neck and head squamous cell carcinomas, cyclin L1 can be overexpressed and is therefore often considered a proto-oncogene. It interacts with POLR2A, CDC2L and SFRS2. Cyclin L1 plays a role in the mRNA splicing process regulation.Synonyms: BM-001, CCNL1, Cyclin-L, Cyclin-L1

Poids moléculaire: approx. 60 kDa

ID gène: 57018

NCBI Accession: NP_064703

UniProt: Q9UK58