THRA anticorps

N° du produit ABIN271852

Détail du produit anti-THRA anticorps

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Thyroid Hormone Receptor protein. (region surrounding Ala19)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA / ERBA1 (THRA Produits)

Synonymes: anticorps AR7, anticorps CHNG6, anticorps EAR7, anticorps ERB-T-1, anticorps ERBA, anticorps ERBA1, anticorps NR1A1, anticorps THRA1, anticorps THRA2, anticorps c-ERBA-1, anticorps C-ERBA-ALPHA, anticorps TRalpha, anticorps c-erba, anticorps erba, anticorps nr1a1-A, anticorps thra-A, anticorps thra1, anticorps TR[a]1, anticorps nr1a1, anticorps thra, anticorps thral, anticorps tra, anticorps tra1, anticorps wu:fb59g07, anticorps Thra1, anticorps 6430529J03Rik, anticorps AW259572, anticorps Erba, anticorps Nr1a1, anticorps Rvr, anticorps T3R[a], anticorps T3Ralpha, anticorps Thra2, anticorps C-ERBA ALPHA1, anticorps Thra, anticorps fTHRalphaA, anticorps nr1a1-a, anticorps thyroid hormone receptor, alpha, anticorps thyroid hormone receptor, alpha L homeolog, anticorps thyroid hormone receptor alpha a, anticorps thyroid hormone receptor alpha, anticorps thyroid hormone receptor alpha-A, anticorps THRA, anticorps thra.L, anticorps thraa, anticorps Thra, anticorps tr-alpha, anticorps LOC109641414

Sujet: Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TRα and TRβ, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRα, RXRβ and RXRγ). To a certain extent, this activity is regulated by differential phosphorylation of TRs. Thus, not only are the biological activities of TRs regulated by heterodimerization with RXRs, but in addition, the gene regulatory activities of TRs are linked to other hormonal pathways. TRα1 can display both a nuclear and undefined cytoplasmic location, and is the only TR that is imported into the mitochondrial matrix.Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1

Poids moléculaire: approx. 55 kDa

ID gène: 7067

NCBI Accession: NP_001177847

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development