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HLA-DR anticorps (HLA-DR) (FITC) Primary Antibody

HLA-DR Reactivité: Chien, Humain, Non-Human Primate Func, IHC (f), ICC, FACS, IP, IHC (p), WB Hôte: Souris Monoclonal L243
Pubmed (6)
N° du produit ABIN2749149
$417.45
Plus shipping costs $45.00
100 tests
local_shipping Destination: Etats-Unis
Envoi sous 5 à 7 jours ouvrables
  • Antigène
    Reactivité
    Chien, Humain, Non-Human Primate
    Hôte
    Souris
    Clonalité
    Monoclonal
    Conjugué
    Cet anticorp HLA-DR est conjugé à/à la FITC
    Application
    Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Specificité
    The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty.
    Réactivité croisée (Details)
    Human, Non-Human Primates, Canine (Dog)
    Immunogène
    Human B lymphocytes
    Clone
    L243
    Isotype
    IgG2a
  • Indications d'application
    The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • De Gassart, Camosseto, Thibodeau, Ceppi, Catalan, Pierre, Gatti: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, 2008 (PubMed).

    Swiatek-de Lange, Rist, Stahl, Weith, Lenter: "Comment on "MHC class II expression identifies functionally distinct human regulatory T cells"." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 6, pp. 3625; author reply 3626, 2008 (PubMed).

    Muczynski, Ekle, Coder, Anderson: "Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression." dans: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 5, pp. 1336-48, 2003 (PubMed).

    Bouillon, El Fakhry, Girouard, Khalil, Thibodeau, Mourad: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." dans: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, 2003 (PubMed).

    Kalka-Moll, Tzianabos, Bryant, Niemeyer, Ploegh, Kasper: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, 2002 (PubMed).

    Coral, Pucillo, Leonardi, Fonsatti, Altomonte, Maio: "Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 8, Issue 5, pp. 581-8, 1997 (PubMed).

  • Antigène
    Autre désignation
    HLA-DR
    Sujet
    HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).
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