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TRAIL anticorps (AA 95-281)
TNFSF10
Reactivité: Humain
FACS
Hôte: Souris
Monoclonal
2E5
unconjugated
N° du produit ABIN2751999
Détail du produit anti-TRAIL anticorps
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Antigène
Voir toutes TRAIL (TNFSF10) Anticorps
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Épitope
Tous les épitopes à travers TRAIL Anticorps.
AA 95-281
Reactivité
Toutes les réactivités sur TRAIL Anticorps
Humain
Hôte
Toutes les hôtes sur TRAIL Anticorps
Souris
Clonalité
Toutes les clonalités sur TRAIL Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers TRAIL Anticorps
Cet anticorp TRAIL est non-conjugé
Application
Tous les applications à travers TRAIL Anticorps.
Flow Cytometry (FACS)
Specificité
The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
Aucune reactivité croisée
Souris
Réactivité croisée (Details)
Human
Purification
Purified by protein-A affinity chromatography.
Pureté
> 95 % (by SDS-PAGE)
Immunogène
Recombinant soluble fragment (aa 95-281) of human TRAIL.
Clone
2E5
Isotype
IgG1
Top Product
Discover our top product TNFSF10 Anticorps primaire
Alternatives
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Information d'application
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Indications d'application
Flow cytometry: Recommended dilution: 1-5 μg/mL.
Restrictions
For Research Use only
Stockage
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Références pour anticorps anti-TRAIL (ABIN2751999)
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Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed : "Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. " dans: Cancer research , Vol. 65 , Issue 11 , pp. 4799-808 , (2005 ) (PubMed ).
Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka : "TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. " dans: Leukemia , Vol. 16 , Issue 1 , pp. 67-73 , (2002 ) (PubMed ).
Détails sur TRAIL
(cache)
Antigène
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Autre désignation
CD253 / TRAIL (TNFSF10 Produits )
Synonymes
anticorps APO2L, anticorps Apo-2L, anticorps CD253, anticorps TL2, anticorps TRAIL, anticorps A330042I21Rik, anticorps AI448571, anticorps APO-2L, anticorps Ly81, anticorps Trail, anticorps tl2, anticorps apo2l, anticorps cd253, anticorps trail, anticorps apo-2l, anticorps trail1, anticorps xtrail1, anticorps tnfsf10l2, anticorps zgc:92320, anticorps TNLG6A, anticorps TNF superfamily member 10, anticorps tumor necrosis factor (ligand) superfamily, member 10, anticorps tumor necrosis factor superfamily member 10, anticorps TNF superfamily member 10 S homeolog, anticorps TNFSF10, anticorps Tnfsf10, anticorps tnfsf10.S, anticorps tnfsf10
Sujet
TNF superfamily member 10,Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).,TRAIL, Apo-2 ligand, Apo-2L, TNFSF10, APO2L, TNLG6A
ID gène
8743
UniProt
P50591
Pathways
Apoptose , Positive Regulation of Endopeptidase Activity
Vus récemment
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