CACNA1C anticorps

N° du produit ABIN2763649

Détail du produit anti-CACNA1C anticorps

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA1C est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Attributs du produit: Voltage-Dependent T-Type Calcium Channel, alpha1G subunit, Cncna1G,Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1g gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. alpha(1G) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway.

Purification: Antigen Immunoaffiinity Purification

Immunogène: Synthetic peptide derived from the rat alpha1G calcium channel conjugated to KLH

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CACNA1C

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Autre désignation: Calcium Channel (CACNA1C Produits)

Synonymes: anticorps CACH2, anticorps CACN2, anticorps CACNL1A1, anticorps CCHL1A1, anticorps CaV1.2, anticorps LQT8, anticorps TS, anticorps Cav1.2, anticorps Cchl1a1, anticorps MBC, anticorps MELC-CC, anticorps RATIVS302, anticorps isl, anticorps C-LTCC, anticorps CHCACHA1C, anticorps ICA, anticorps cav1.2, anticorps ca(v)1.2, anticorps CAV1.2, anticorps BCR, anticorps rbc, anticorps calcium voltage-gated channel subunit alpha1 C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit, anticorps voltage-dependent L-type calcium channel subunit alpha-1C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog, anticorps Red blood cell count, anticorps RNA, 7SL, cytoplasmic 263, pseudogene, anticorps CACNA1C, anticorps Cacna1c, anticorps cacna1c, anticorps LOC100442085, anticorps cacna1c.S, anticorps RBC, anticorps RN7SL263P

Pathways: Hormone Transport, Carbohydrate Homeostasis