NR1H4 anticorps (Middle Region)

N° du produit ABIN2773865

Détail du produit anti-NR1H4 anticorps

Antigène: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Chien, Cheval, Boeuf (Vache), Lapin, Porc, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1H4 est non-conjugé

Application: Western Blotting (WB)

Séquence: SAVEAMFLRS AEIFNKKLPS GHSDLLEERI RNSGISDEYI TPMFSFYKSI

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against NR1H4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NR1H4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 472 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NR1H4 (ABIN2773865)

Yamada, Osawa, Hamaya, Furuta, Hishida, Kajimura, Ikuma: "Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells." dans: Anticancer research, Vol. 30, Issue 6, pp. 1953-60, (2010) (PubMed).

Détails sur NR1H4

Antigène: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Autre désignation: NR1H4 (NR1H4 Produits)

Synonymes: anticorps zgc:110190, anticorps zgc:92742, anticorps NR1H4, anticorps BAR, anticorps FXR, anticorps HRR-1, anticorps HRR1, anticorps RIP14, anticorps AI957360, anticorps Fxr, anticorps Rxrip14, anticorps nuclear receptor subfamily 1, group H, member 5 S homeolog, anticorps nuclear receptor subfamily 1, group H, member 4, anticorps nuclear receptor subfamily 1 group H member 4, anticorps nr1h5.S, anticorps nr1h4, anticorps NR1H4, anticorps Nr1h4

Sujet: NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d
Alias Symbols: BAR, FXR, HRR-1, HRR1, MGC163445, RIP14
Protein Interaction Partner: SMARCD3, HDAC6, SUMO1, NCOR2, ESR1, RRM2, GPS2, RXRG, GAPDH, RXRA, EP300, SIRT1, SRC, NCOA6, CARM1, HIST1H4A, HIST1H3A, PRMT1, NCOR1, XRCC5, PRKDC, XRCC6, NCOA1, CASP8, SMARCD1,
Protein Size: 472

Poids moléculaire: 54 kDa

ID gène: 9971

NCBI Accession: NM_005123, NP_005114

UniProt: B6ZGS9

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process