SCN5A anticorps (C-Term)

N° du produit ABIN2776347

Détail du produit anti-SCN5A anticorps

Antigène: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCN5A est non-conjugé

Application: Western Blotting (WB)

Séquence: FTKRVLGESG EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SCN5A. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SCN5A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 2015 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SCN5A (ABIN2776347)

Askar, Bingen, Schalij, Swildens, Atsma, Schutte, de Vries, Zeppenfeld, Ypey, Pijnappels: "Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." dans: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).

Costa, Panda, Yong, Mayorga, Pawlowski, Fan, Penn, Laurita: "Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells." dans: American journal of physiology. Heart and circulatory physiology, Vol. 302, Issue 1, pp. H270-7, (2011) (PubMed).

Colussi, Berni, Rosati, Straino, Vitale, Spallotta, Baruffi, Bocchi, Delucchi, Rossi, Savi, Rotili, Quaini, Macchi, Stilli, Musso, Mai, Gaetano, Capogrossi: "The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice." dans: Cardiovascular research, Vol. 87, Issue 1, pp. 73-82, (2010) (PubMed).

House, Vaske, Schwartz, Obias, Frank, Luu, Sarvazyan, Irby, Strausberg, Hales, Stuart, Lee: "Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion." dans: Cancer research, Vol. 70, Issue 17, pp. 6957-67, (2010) (PubMed).

Détails sur SCN5A

Antigène: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Autre désignation: SCN5A (SCN5A Produits)

Synonymes: anticorps Nav1.5, anticorps Nav1.5c, anticorps SkM1, anticorps SkM2, anticorps mH1, anticorps CDCD2, anticorps CMD1E, anticorps CMPD2, anticorps HB1, anticorps HB2, anticorps HBBD, anticorps HH1, anticorps ICCD, anticorps IVF, anticorps LQT3, anticorps PFHB1, anticorps SSS1, anticorps VF1, anticorps SCAL, anticorps sodium voltage-gated channel alpha subunit 5, anticorps sodium channel, voltage-gated, type V, alpha, anticorps SCN5A, anticorps Scn5a

Sujet: SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram.The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform.
Alias Symbols: CDCD2, CMD1E, CMPD2, HB1, HB2, HH1, IVF, LQT3, Nav1.5, SSS1, VF1, HBBD, ICCD, PFHB1
Protein Interaction Partner: CALM1, CAV3, ALB, Nedd4, WWP2, UBC, SNTG2, NEDD4L, DLG2, INADL, DLG4, RGS3, SNTA1, DLG1, RGS2, SCN5A, SNTB2, SNTB1, DLG3, CBL,
Protein Size: 2015

Poids moléculaire: 222 kDa

ID gène: 6331

NCBI Accession: NM_000335, NP_000326

UniProt: Q8IZC9