EED anticorps (N-Term)

N° du produit ABIN2776406

Détail du produit anti-EED anticorps

Antigène: EED (Embryonic Ectoderm Development (EED))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EED est non-conjugé

Application: Western Blotting (WB)

Séquence: AKKQKLSSDE NSNPDLSGDE NDDAVSIESG TNTERPDTPT NTPNAPGRKS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Eed. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 441 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EED

Antigène: EED (Embryonic Ectoderm Development (EED))

Autre désignation: Eed (EED Produits)

Synonymes: anticorps Xeed, anticorps heed, anticorps wait1, anticorps EED, anticorps HEED, anticorps WAIT1, anticorps zgc:112509, anticorps Xeed-B, anticorps eed, anticorps psXEED, anticorps ENSMUSG00000039373, anticorps l(7)5Rn, anticorps l7Rn5, anticorps lusk, anticorps Xeed-A, anticorps embryonic ectoderm development, anticorps embryonic ectoderm development S homeolog, anticorps microRNA 6755, anticorps embryonic ectoderm development L homeolog, anticorps eed, anticorps EED, anticorps eed.S, anticorps MIR6755, anticorps Eed, anticorps eed.L

Sujet: Eed is a polycomb group (PcG) protein. It is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Eed plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Eed is required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. Eed may prevent transcriptional activation of facultative heterochromatin during differentiation. Eed is required for development of secondary trophoblast giant cells during placental development. Eed may regulate hippocampal synaptic plasticity in the developing brain.
Alias Symbols: ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
Protein Interaction Partner: Ezh2, Suz12, Rab3gap1, Ddx47, Nop10, Nip7, Bola2, Tmem14c, Uqcr10, Eif3f, Cbwd1, Smc5, Etf1, Svil, Fbxo11, Srsf7, Safb, Safb2, Abcf1, Bag6, C330027C09Rik, Pak2, Pphln1, Ttll12, Sun2, Tomm22, Eif3l, E430025E21Rik, Eny2, Dcaf13, Trio, Ccar2, Fermt2, Vps41,
Protein Size: 441

Poids moléculaire: 50 kDa

ID gène: 13626

NCBI Accession: NM_021876, NP_068676

UniProt: Q921E6