MBNL2 anticorps (Middle Region)
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- Antigène Voir toutes MBNL2 Anticorps
- MBNL2 (Muscleblind-Like 2 (MBNL2))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Poisson zèbre (Danio rerio), Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MBNL2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- IACFDSLKGR CSRENCKYLH PPTHLKTQLE INGRNNLIQQ KTAAAMLAQQ
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Mbnl2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of RAT Mbnl2
- Top Product
- Discover our top product MBNL2 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MBNL2 (Muscleblind-Like 2 (MBNL2))
- Autre désignation
- Mbnl2 (MBNL2 Produits)
- Synonymes
- anticorps 1110002M11Rik, anticorps AI047808, anticorps AI837313, anticorps AI849185, anticorps AL118326, anticorps MBLL, anticorps R75232, anticorps mKIAA4072, anticorps wu:fj89c04, anticorps MBLL39, anticorps PRO2032, anticorps muscleblind like splicing factor 2, anticorps muscleblind-like splicing regulator 2, anticorps muscleblind like splicing regulator 2, anticorps Mbnl2, anticorps mbnl2, anticorps MBNL2
- Sujet
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Mbnl2 mediates pre-mRNA alternative splicing regulation. It acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. It antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. It seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. It may play a role in myotonic dystrophy pathophysiology (DM).
Protein Size: 378 - Poids moléculaire
- 41 kDa
- ID gène
- 680445
- UniProt
- F2Z3T4
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