SLC12A1 anticorps (N-Term)

N° du produit ABIN2776780

Détail du produit anti-SLC12A1 anticorps

Antigène: SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))

Épitope: N-Term

Reactivité: Rat, Humain, Souris, Chien, Porc, Lapin, Cobaye, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC12A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: NEKKSRGFFN YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SLC12A1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC12A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 430 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SLC12A1 (ABIN2776780)

Yoshioka, Kawaguchi, Nishimura, Akagi, Fujisawa, Yanagisawa, Matsumura, Tohyama: "Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice." dans: American journal of physiology. Renal physiology, Vol. 311, Issue 4, pp. F752-F762, (2016) (PubMed).

Stec, Drummond, Gousette, Storm, Abraham, Csongradi: "Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension." dans: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 5, pp. 834-41, (2012) (PubMed).

Kelsen, Patel, Parker, Vera, Rimoldi, Gadepalli, Drummond, Stec: "Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells." dans: American journal of physiology. Renal physiology, Vol. 295, Issue 4, pp. F1158-65, (2008) (PubMed).

Détails sur SLC12A1

Antigène: SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))

Autre désignation: SLC12A1 (SLC12A1 Produits)

Synonymes: anticorps slc12a1, anticorps SLC12A1, anticorps DKFZp469A2020, anticorps BSC1, anticorps NKCC2, anticorps Nkcc2, anticorps AI788571, anticorps D630042G03Rik, anticorps mBSC1, anticorps urehr3, anticorps si:ch211-220f12.1, anticorps solute carrier family 12 member 1, anticorps solute carrier family 12, member 1, anticorps si:ch211-220f12.1, anticorps SLC12A1, anticorps Slc12a1

Sujet: The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
Alias Symbols: BSC1, MGC48843, NKCC2
Protein Interaction Partner: STK39, OXSR1,
Protein Size: 430

Poids moléculaire: 47 kDa

ID gène: 6557

NCBI Accession: NM_000338

UniProt: Q8IUN5