STAT6 anticorps (C-Term)

N° du produit ABIN2777200

Détail du produit anti-STAT6 anticorps

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: NLYPKKPKDE AFRSHYKPEQ MGKDGRGYVP ATIKMTVERD QPLPTPELQM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against STAT6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human STAT6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 847 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur STAT6

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Autre désignation: STAT6 (STAT6 Produits)

Synonymes: anticorps D12S1644, anticorps IL-4-STAT, anticorps STAT6B, anticorps STAT6C, anticorps signal transducer and activator of transcription 6, anticorps signal transducer and activator of transcription 6-like, anticorps STAT6, anticorps Stat6, anticorps LOC100859543

Sujet: Full-length human STAR6 (NP_003144) was expressed in E.coli as inclusion body and purified after protein refolding for mouse immunization. Clone 5B1 shows excellent western blot detection of endogenous STAT6 using ACHN cell lysate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: D12S1644, IL-4-STAT, STAT6B, STAT6C
Protein Interaction Partner: UBC, IRF4, PDE12, EHD1, USP8, API5, PGGT1B, EP300, TRIM28, JAK3, RCN3, LITAF, IL4R, EEF1A1, VKORC1, PTPN2, STAT2, JAK1, IFNG, IFNAR1, SRXN1, PSAT1, DSTN, SEC24A, AHCYL1, SSSCA1, NUBP2, SH3BGRL, RAD23B, PPM1G, IGBP1, CEBPE, SND1, SUMO2, FCER2, SFPQ, IGHE,
Protein Size: 847

Poids moléculaire: 94 kDa

ID gène: 6778

NCBI Accession: NM_003153, NP_003144

UniProt: P42226

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response