NR1H2 anticorps (Middle Region)

N° du produit ABIN2777961

Détail du produit anti-NR1H2 anticorps

Antigène: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1H2 est non-conjugé

Application: Western Blotting (WB)

Séquence: ETECITFLKD FTYSKDDFHR AGLQVEFINP IFEFSRAMRR LGLDDAEYAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NR1H2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NR1H2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 461 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NR1H2 (ABIN2777961)

Fu, Mukhamedova, Ip, DSouza, Henley, DiTommaso, Kesani, Ditiatkovski, Jones, Lane, Jennings, Smyth, Kile, Sviridov: "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis." dans: Cell metabolism, Vol. 18, Issue 2, pp. 225-38, (2013) (PubMed).

Détails sur NR1H2

Antigène: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Autre désignation: NR1H2 (NR1H2 Produits)

Synonymes: anticorps NR1H2, anticorps lxr-b, anticorps lxrb, anticorps ner, anticorps ner-i, anticorps rip15, anticorps unr, anticorps DKFZp468A0622, anticorps AI194859, anticorps LXR, anticorps LXRB, anticorps LXRbeta, anticorps NER1, anticorps OR-1, anticorps RIP15, anticorps UR, anticorps Unr, anticorps Unr2, anticorps LXR-b, anticorps NER, anticorps NER-I, anticorps UNR, anticorps nuclear receptor subfamily 1 group H member 2, anticorps nuclear receptor subfamily 1, group H, member 2, anticorps nuclear receptor subfamily 1 group H member 2 L homeolog, anticorps NR1H2, anticorps nr1h2, anticorps Nr1h2, anticorps nr1h2.L

Sujet: NR1H2 is an orphan receptor. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: LXR-b, LXRB, NER, NER-I, RIP15, UNR
Protein Interaction Partner: RXRG, MDFI, KDM1A, SUV39H1, ACVRL1, LAMC3, NCOR2, YY1, NPY, CDKN1A, PPARGC1B, PDCD4, PIAS1, USP7, PRKCA, SENP3, CORO2A, MPP1, COL4A5, CHD3, RMI1, CSAD, DUSP12, C14orf1, FAF1, SPRY2, HMGXB4, SORBS2, BAG6, VIM, UBE2D1, SMPD1, ROBO2, NCOR1, NRIP1, NCOA3, VDR
Protein Size: 461

Poids moléculaire: 51 kDa

ID gène: 7376

NCBI Accession: NM_007121, NP_009052

UniProt: P55055

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding